Doctoral Researcher (Systems Biology, Bioinformatics, Biophysics) / Väitöskirjatutkija (systeemibio

Doctoral Researcher (Systems Biology, Bioinformatics, Biophysics) / Väitöskirjatutkija (systeemibiologia, bioinformatiikka, biofysiikka)

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The Laboratory of Biosystems Dynamics (LBD) of the Faculty of Medicine and Health Technology of Tampere University is looking for a Doctoral Researcher for a project funded by the Sigrid Juselius Foundation.

This project will study how the Gene Regulatory Network of Klebsiella pneumoniae responds to antibiotics, including its Dynamics, Mechanisms, Sensitivity, Specificity, Single-cell Variability, and Vulnerabilities.

Our group is multi-disciplinary, combining methods from Bioinformatics (RNA-seq, biological databases), Computational Biology (stochastic and analytical models of gene expression), Signal Processing (machine learning, image and signal processing), Biophysics, Microbiology and Single-cell Biology (flow cytometry, microscopy, synthetic biology, etc.).

Job description

We are looking for a Doctoral Researcher with a background in Systems Biology / Bioinformatics / Biophysics , or equivalent.

The PhD student will join an international team that studies bacterial transcriptional programs of antibiotic adaptation combining theoretical and experimental methods. The student will also participate in national and international collaborations with teams from Finland, Sweden, USA, Canada, Portugal, UK, India, etc.

Figure 1: We will use models, data analysis, and new empirical genome-wide and single-cell data to study how non-resistant bacteria increase antibiotics survivability, focusing on their gene networks. Our laboratory produces experimental data that will be analyzed by the student to study the bacterial gene network and develop new, realistic models