Clinical Pharmacometrician in CVRM (Associate Director/Senior Scientist)

About this role

Responsibilities

• Working closely with clinical pharmacologists, physicians, statisticians and other scientists, you will apply model informed drug development (MIDD) to contribute to clinical programs, to support the design and interpretation of clinical studies and influence key decisions in early and late clinical development.
• The work includes integration of relevant data, such as dose information, pharmacokinetics, biomarkers and clinical endpoints within and across studies, compounds and development stages. Use of simulations and pharmacometric/statistical analyses to inform trial and program designs and decisions are important focus areas for us.
• In collaboration with clinical pharmacologists, you will represent CPQP in cross-functional clinical project teams and be responsible for identifying and driving model informed drug development opportunities, to accelerate and advise decision making. Based on your interest, skills and experience, you might also take on strategic planning and delivery of the clinical pharmacology strategy acting as a dual Clinical Pharmacometrician/Clinical Pharmacologist. You will communicate your findings within and outside of AstraZeneca and publish in peer reviewed journals.
• Minimum requirements for the role
• PhD in pharmacometrics or mathematical/statistical modeling and simulation or other relevant area
• Strong quantitative skills (e.g. experience in population modelling, statistics, systems and translational pharmacology modelling)
• Strong technical knowledge and hands-on skills in PK and PK/PD modeling and simulation including training and experience with pharmacometric and statistical software (NONMEM, R, Stan, Monolix, Phoenix)
• Knowledge in pharmacology and drug targets
• Excellent oral and written communication skills
• Desirable requirements
• 4+ years of industry experience or equivalent in quantitative modelling and its application in drug development combined with ability to independently support clinical programs is required for Associate Director level (2+ years for Senior Scientist)
• 2+ years of industry experience or equivalent in quantitative modelling and its application in drug development combined is required for Senior Scientist level
• Track record in creating and delivering on MIDD strategies in clinical drug development programs for both small and large molecules
• Early and late phase clinical development experience
• Understanding of clinical pharmacology aspects of drug development, preferably in both a small and large molecule setting
• Recognized scientific expertise demonstrated by scientific publishing in the field of clinical pharmacometrics/pharmacology
• Knowledge in Cardiovascular, Renal or Metabolism disease areas
• Familiarity with applications of artificial intelligence in drug development is a strong plus
• Why AstraZeneca?
• At AstraZeneca, we are at the forefront of medical innovation. We use our unique position as medical leaders across our enterprise and the healthcare ecosystem to shape the future of healthcare. We provide medical leadership across the whole product lifecycle - from advising on Research & Development investment decisions, to leading pre-launch scientific efforts and accelerating evidence-based healthcare changes in the real world. We are networkers and influencers by nature. In our role as scientific ambassadors, we thrive on working with people internally and externally.
• When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.
• So, what’s next?
• Are you prepared to bring your innovative ideas and fresh perspectives to the table? If so, you might be the candidate we're seeking! Please submit your application by
• 3rd May 2026.
• Please ensure your application includes your current CV and a cover letter highlighting your key strengths and explaining why you should be considered for the role.
• Date Posted
• 13-Apr-2026
• Closing Date
• 03-May-2026
• Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.