Senior Clinical PBPK Modeling Scientist
About this role
T
he ideal candidate will have
strong
background in pharmacokinetics and translational modeling. You will
participate
in implementing innovative and quantitative approaches to advance clinical drug development.
Developing, qualifying, and applying mechanistic PBPK models
using in
vitro, preclinical, clinical, and literature data to support clinical development decisions across therapy
areas
.
In addition, you will have opportunities to contribute to broader areas within Clinical Pharmacology & Quantitative Pharmacology
(CPQP)
as
per
your experience
, interests,
and
expertise
dictate
.
Typical Accountabilities
Utilize
physiologically-based
pharmacokinetic (
PBPK
)
and translational modeling tools to enable clinical PK projections for
drug-drug interactions (
DDIs
)
, pediatric and other specific populations, and other clinical development questions
Collaborate with
Drug Metabolism and Pharmacokinetic (
DMPK
) Scientists
and Clinical Pharmacology scientists to generate these mechanistic models
Develop fit-for-purpose, qualified PBPK models suitable for internal decision-making and regulatory use, including support for
submission
documentation and health authority
interactions
.
Communicate
clearly and effectively both internally and externally on topics related to PBPK clinical DDI and pediatric and other specific populations predictions
Keep up to date with emerging literature, modeling science, and regulatory expectations
Education, Qualifications,
Requirements
- and Experience
- PhD degree preferred or equivalent (M.Sc./Pharm.D.)
- Experience using PBPK platforms such as
- Simcyp
- ,
- GastroPlus
- , or PK-Sim, together with scripting in R and/or Python for data analysis, visualization, and workflow automation.
- Familiarity with AI-enabled scientific workflows, such as literature mining, coding
- assistance
- , or document summarization in compliant research environments
- Demonstrated broad
- PBPK
- expertise
- and experience exemplified by
- 1
- 4
- Years of drug development experience, with emphasis on
- PBPK model
- l
- ing
- Good knowledge in
- pharmacokinetics, drug-drug interactions, regulatory guidance in clinical pharmacology,
- modelling
- and simulation sciences
- Demonstrated ability to
- identify
- ,
- develop
- and execute
- PBPK
- activities at a project level
- Good oral and written communication skills
- Good knowledge of global regulatory, compliance, processes,
- standards
- and issues specific to
- PBPK
- with relevant experience
- Experience authoring or contributing to PBPK technical reports and regulatory documentation, including submission-ready analyses and responses to health authority queries
- .
- Fluency in spoken and written English language
Nice to have
- A
- reputation gained from scientific publishing in the field of DMPK/Clinical Pharmacology
- Experience in early and
- late-stage
- drug development
- Date Posted
- 11-ago-2026
- Closing Date
- 30-ago-2026
- AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.