Senior Scientist I / II – Translational Experimental Cancer Biology (OTR)

About this role

Responsibilities

• Lead mechanism-of-action studies to interrogate therapeutic response and resistance in breast cancer models
• Design and execute in vitro assays to uncover intrinsic and acquired resistance pathways
• Engineer and optimize human cell line models for functional screening and mechanistic investigations
• Collaborate cross-functionally across discovery, data science, and early clinical development teams
• Analyze, interpret, and clearly communicate experimental data to drive translational insights
• Document experiments rigorously and maintain high-quality scientific records and reproducibility standards
• Stay current with emerging scientific literature and integrate new methodologies into research strategies

Requirements

• Doctor of Philosophy in biology, cancer biology, molecular biology, or a related scientific discipline
• Strong expertise in cell biology and advanced molecular biology techniques
• Proven experience studying resistance to small molecule therapies using molecular approaches
• Deep understanding of hormone-driven cancer biology, including breast or prostate cancer
• Experience designing and executing in vitro assays to investigate cellular mechanisms
• Demonstrated ability to engineer and work with human cell line models
• Strong problem-solving skills, scientific curiosity, and ability to interpret complex biological data
• Proven ability to collaborate effectively within multidisciplinary scientific teams
• Desirable Requirements
• Experience with data mining and computational analysis applied to biological datasets
• Familiarity with single-cell sequencing or spatial transcriptomics approaches
• Novartis Compensation and Benefit Summary:
• The salary for this position is expected to range between $98,700.00 - 183,300.00 USD Annual per year.
• The final salary offered is determined based on factors like, but not limited to, relevant skills and
• experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published
• salary range based on company and market factors.
• Your compensation will include a performance-based cash incentive and, depending on the level of the
• role, eligibility to be considered for annual equity awards.
• US-based eligible employees will receive a comprehensive benefits package that includes health, life and
• disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In
• addition, employees are eligible for a generous time off package including vacation, personal days,
• holidays and other leaves.