Sr. Scientist I /II - Pharmacology

About this role

Responsibilities

• Execute preclinical in vivo studies, including dosing, tumor implantation, monitoring, and tissue and blood collection, following standard operating procedures.
• Develop and apply in vivo oncology models to assess antitumor activity, biomarkers, and pharmacokinetic and pharmacodynamic relationships.
• Design, optimize, troubleshoot, and analyze multicolor flow cytometry panels to characterize tumor and peripheral immune responses.
• Perform ex vivo and in vitro workflows, including cell culture, tumor cell preparation, and tissue processing into single-cell suspensions.
• Generate and interpret high-quality datasets using flow cytometry analysis software and GraphPad Prism for visualization and summaries.
• Maintain accurate experimental documentation in an electronic laboratory notebook and contribute to study reports and presentations.
• Collaborate across functions to communicate findings clearly, support study planning, and advance oncology discovery priorities.

Requirements

• Bachelor’s or Master’s degree in Immunology, Biology, or a related scientific field, with relevant laboratory experience.
• Hands-on experience with mouse in vivo studies, including dosing, tumor implantation, monitoring, and tissue collection.
• Experience working with oncology in vivo models, including xenograft or syngeneic systems.
• Strong multicolor flow cytometry expertise, including panel design, optimization, troubleshooting, and data analysis.
• Experience with flow cytometry analysis software such as FlowJo.
• Demonstrated ability to execute experiments independently while producing high-quality, reproducible data.
• Strong data interpretation skills and the ability to present results clearly in a multidisciplinary setting.
• Strong attention to detail, organization, and a collaborative, proactive working style.
• Desirable requirements
• Experience establishing cell line-derived xenograft, patient-derived xenograft, or syngeneic tumor models for oncology studies.
• Experience with immune profiling of tumors and secondary lymphoid organs using multicolor flow cytometry.
• Novartis Compensation and Benefit Summary:
• The salary for this position is expected to range between $93,800.00 - 174,200.00 USD Annual per year.
• The final salary offered is determined based on factors like, but not limited to, relevant skills and
• experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published
• salary range based on company and market factors.
• Your compensation will include a performance-based cash incentive and, depending on the level of the
• role, eligibility to be considered for annual equity awards.
• US-based eligible employees will receive a comprehensive benefits package that includes health, life and
• disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In
• addition, employees are eligible for a generous time off package including vacation, personal days,
• holidays and other leaves.