Scientist, Bioscience – Cell & Mechanistic Biology

About this role

Responsibilities

• As a Scientist in Bioscience, with expertise in cell and molecular biology, you will support haematology-oncology drug discovery programs across our Oss and future Amsterdam sites.
• You will design and execute innovative cell-based assays that drive the design-make-test-analyze (DMTA) cycle, while leading mechanistic studies to uncover compound mechanisms of action and pathway biology.
• We are particularly interested in candidates with strong hands-on expertise in flow cytometry, including multicolor panel design, assay development, and high-dimensional data analysis.
• The ideal candidate combines excellent laboratory skills with scientific curiosity, critical thinking, and a passion for translating complex biological data into meaningful insights.
• Experience in haematology-oncology research and pharmaceutical drug discovery is highly valued.
• What you’ll be doing
• Develop and optimise flow cytometry assays, including multicolor panel design, gating strategies, and cellular profiling
• Design and validate cell-based assays to support proliferation, pathway activation, target engagement, and degradation studies
• Perform mechanistic studies using CRISPR/Cas9, RNAi, and pharmacological approaches to investigate compound activity and pathway biology
• Work with haematology-oncology disease models, including AML, CLL, MM, co-culture systems, and 3D/spheroid models
• Apply molecular biology techniques such as cloning, qPCR, Western blotting, and immunoassays
• Analyse and interpret complex biological datasets and translate findings into clear scientific recommendations
• Maintain accurate ELN documentation and present results to multidisciplinary project teams
• Support collaboration, knowledge sharing, and guidance of junior scientists where appropriate
• What you bring
• MSc in Molecular Biology, Cell Biology, Cancer Biology, Pharmacology, or a related field, or a relevant Bachelor/HBO degree with 5+ years of industry experience in drug discovery and cell biology
• Experience within biotech or pharma environments supporting DMTA-driven discovery programs
• Strong hands-on expertise in flow cytometry, cellular assay development, and biological data analysis
• Experience with general cell and mol bio techniques (tissue culture, western, qPCR)
• Strong scientific reasoning skills, a structured way of working, and excellent collaboration and communication skills
• Fluency in English and willingness to work in Oss until the transition to Amsterdam in early 2027
• Please note: this role is intended for candidates with a BSc or MSc background. A PhD profile will not be a suitable match due to the hands-on and operational focus of the position.
• Preferred Qualifications
• 3–5 years of advanced flow cytometry experience in complex biological systems
• Experience with high-parameter panel design, compensation strategies, and cell sorting
• Experience with haematology-oncology models, primary patient samples, or 3D/spheroid systems is considered a plus
• Familiarity with major cytometry platforms (e.g. BD systems), including troubleshooting and maintenance
• Expertise in CRISPR/Cas9, RNAi, cloning, qPCR, Western blotting, ELISA/HTRF, or reporter assays
• Hands-on experience with AML, CLL, MM, or related haematological models
• Experience working with primary patient samples and human materials under ethical and biosafety frameworks
• Experience with with 3D/spheroid cultures and live-cell imaging platforms such as Incucyte