Associate Principal Scientist / Sr Scientist: Computational Chemistry
About this role
Join a world leading team in developing the next generation of small molecule and PROTACs medicines!
AstraZeneca R&D, Gothenburg, Sweden seeks to recruit into Computational Chemistry, BioPharma Chemistry, Discovery Sciences.
About the position
As a Computational Chemist you will have a profound impact on multiple projects across the BioPharma portfolio. You will work collaboratively with medicinal chemists and multidisciplinary teams across all discovery phases. You will efficiently and proactively apply a full range of computational chemistry and AI approaches to deliver design, predictive models and SAR-analysis to improve potency, selectivity, activity and/or ADMET properties of our drug compounds.
You will help identify scientific improvement areas in computational sciences and assess their application to AstraZeneca projects, while contributing to new computational capabilities through collaboration with external partners and colleagues across AZ sites. The role offers opportunities to publish original research and reviews in peer reviewed journals and requires maintaining up to date awareness of the literature and developments in the field.
You’ll work alongside a large community of computational chemists across functions—spanning cheminformatics, molecular simulations, structure‑ and ligand‑based design, machine learning and model development—in a collaborative, cross‑disciplinary environment. You’ll also have access to shared high‑performance compute clusters and state‑of‑the‑art software to enable co‑folding, FEP/MD, and advanced modelling workflows such as generative design.
Reponsibilities
We are seeking an engaged computational chemist with a solid knowledge of drug discovery concepts and a proven track record of applying computational chemistry techniques with measurable impact on drug discovery project delivery. The candidate is expected to have a deep understanding of how computational chemistry contributes to drug discovery projects togethe