Chemistry Lead, Bivalent Modalities

About this role

Responsibilities

• We are seeking a highly experienced and visionary Medicinal Chemist to join our Medicine Design organization as a Chemistry Lead - a key role where you will help define scientific strategy, enable breakthrough discoveries in modern therapeutic modalities, and shape the future of innovative treatments.
• In this senior science-focused role, you will provide scientific leadership to chemists and guide compound design and optimization within discovery projects.
• You will drive medicinal chemistry strategies across a diverse portfolio, with a particular emphasis on next generation modalities, including PROTACs, RIPTACs, and other emerging bifunctional proximity induced approaches. Expertise in the design and ADME optimization of linkers and related chemical architectures will be central to success in this role.
• Importantly, this position will play a pivotal role in building and strengthening our organizational capability in bivalent induced proximity modalities, helping to establish the scientific, technical, and strategic foundations needed for long-term excellence in this area.
• This is a permanent and on-site position with a six-month probationary period, based in Espoo, Finland. Work is primarily conducted during regular daytime hours from Monday to Friday, with flexible working arrangements available.
• Lead medicinal chemistry optimization across discovery programs by shaping hypotheses, prioritizing design strategies, and ensuring high quality decision making throughout the DMTA cycle.
• Provide scientific leadership and expert guidance to the chemistry team and strengthening the team's technical capabilities.
• Design and optimize bivalent induced proximity modalities, such as PROTACs, and RIPTACs, encompassing target binder development, ligand optimization, linker engineering, and advancement of bRo5 chemical matter.
• Integrate multidisciplinary insights - from structural biology, computational modeling (e.g.,